My thoughts: While high dose vitamin C injections may be very helpful in reducing inflammation, improving quality of life and induce cancer cell death they may also increase the risk of cardiovascular events and should be done after an cardiovascular evaluation (at least by blood lipid testing) by a doctor trained in IV vitamin C administration.
Results on 45 people with prostate cancer, breast cancer, bladder cancer, pancreatic cancer, lung cancer, thyroid cancer, skin cancer and B-cell lymphoma treated at the Riordan Clinic: "According to our data positive response to treatment, which was demonstrated by measurements of C- reactive protein, was found in 75% of patients and progression of the inflammation in 25% of patients. IVC treatments on all aggressive stage cancer patients showed the poor response of treatment. There was correlation between tumor markers (PSA, CEA, CA27.29 and CA15-3) and changes in the levels of C-reactive protein. Our test of the effect of IVC on pro-inflammatory cytokines demonstrated that inflammation cytokines IL-1α, IL-2, IL-8, TNF-α, chemokine eotaxin and CRP were reduced significantly after treatments."
"Here, we examined the procoagulant and prothrombotic risks associated with the intravenous injection of gram-dose vitamin C... Indeed, the intravenous injection of vitamin C (0.5–1.0 g/kg) in rats in vivo significantly increased thrombosis. Notably, the prothrombotic effects of vitamin C were more prominent in RBCs isolated from cancer patients, who are at increased risks of thrombotic events. Vitamin C-induced procoagulant and prothrombotic activation of RBCs, and increased thrombosis in vivo. RBCs from cancer patients exhibited increased sensitivity to the prothrombotic effects of vitamin C."
Article - Interview: Are Liposome-encapsulated Vitamin C and/or the Levy Multi-C Protocol more effective than Intravenous Vitamin C? - Part 2
"While research on this subject is yet to be published, Dr. Ron Hunninghake of the Riordan Clinic and I have been working on models of enhancing vitamin C uptake inside the cells with not only insulin, but also hydrocortisone. It appears that after ingestion of vitamin C orally, the intravenous administration of hydrocortisone results in large increases in intracellular vitamin C levels. Furthermore, Marik's work indicates that perhaps much lower amounts of vitamin C (a few grams) given much more frequently (every 4 to 6 hours) could be substantially more effective than much larger amounts of vitamin C (50 to 100 grams) given over an hour or two. Along these lines, Dr. Hunninghake and I are pursuing clinical research involving the steady infusion of vitamin C periodically spiked by multigram vitamin C IV pushes for a variety of conditions. Of note, Dr. Klenner speculated many years ago that giving 300 grams of vitamin C infused around the clock could be especially impactful on cancer and other chronic diseases. Dr. Klenner's genius still amazes me."
Article - Vitamin C in the critically ill - indications and controversies
"Core tip: An increasing body of evidence suggests that high-dose vitamin C administration improves hemodynamics, end-organ function, and may improve survival in critically ill patients. This article reviews studies that evaluate vitamin C in pre-clinical models and clinical trials with respect to its therapeutic potential... A majority of the prospective and case studies of vitamin C administration for cancer-related pain have reported improvements in quality-of-life indicators such as pain, fatigue, insomnia, nausea and vomiting[110-115]."