Bibliography - By Topic
Case study - An interesting case of possible abscopal effect in malignant melanoma.
Unfortunately I could not get the full text of this article, but I could at least get a summary. The patient experienced remission from late stage melanoma after having a wide excision, lymphangiogram and radiation to his inguinal (groin) region. However, unfortunately he had a sudden severe rectal hemorrhage after one year (I suspect it's likely due to the radiation) and passed away.
"The natural history of malignant melanoma is notoriously unpredictable. Although long term survival is not uncommon, lymph node involvement lowers the five yr survival rate to about 5%. It is generally accepted that radiation has no place in the treatment of metastases despite occasional reports of temporary tumor regression. In these cases the response to irradiation occurred in the treated area and simultaneous regression of distant untreated metastases has never been reported. Such behavior has been given the term 'abscopal effect'. It occurs not uncommonly in leukaemia but is extremely rare in other tumors and the case reported is therefore of interest. The patient was a 28 yr old male, who had had a melanoma on the lateral side of the right knee for many years. A wide excision of the melanoma with a skin graft was performed. A lymphangiogram carried out on the right leg showed extensive involvement of the glands in the right inguinal region, with abnormal lymphatic channels in the pelvis. There was failure to fill the right lumbar chain, with deviation of the contrast into the grossly abnormal left lumbar chain. The patient was treated with a full course of fast neutrons (1,440 rad in 12 fractions over 35 days) to the right inguinal region. The upper medial limit of the field was the inferior border of the right sacroiliac joint. A repeat lymphangiogram showed a remarkable regression from the initial very abnormal picture and nine mth after treatment was started, the lymphangiogram was normal. At laparotomy no metastases were found, either in the iliac or para aortic nodes. He remained clinically free of disease during one year when a sudden severe rectal haemorrhage resulted in his death. At post mortem there was no evidence of residual metastatic melanoma."
Immunologic Correlates of the Abscopal Effect in a Patient with Melanoma
This was published in 2012, not long after the observed patient experienced regression but not remission from her melanoma, after receiving both ipilimumab and radiation treatments. I have not seen any follow-up to learn of her long-term outcome.
(Brain metastases specifically)
Case Report of Extended Survival and Quality of Life in a Melanoma Patient with Multiple Brain Metastases and Review of Literature
The patient had melanoma found in her neck (a mass) and a scalp lesion. She had a biopsy which proved the scalp lesion was melanoma and surgery to remove the mass. That same month they found on a PET scan on the other side of her neck hypermetabolic activity and she underwent surgery to remove 28 lymph nodes (including 3 that tested positive for melanoma); the surgery left positive margins (cancerous cells were left in the surgical site). She had two additional excisions of other scalp lesions. Then she received radiation to her scalp and neck, followed by three cycles of cisplatinum, interferon, and vinblastine, then interleukin-2. 9 months after completing the therapy they found a nodule in her retroperitoneum and 3 brain metastases. She had gamma knife radiation to the brain lesions and stereotactic ablative radiotherapy (SABR) to a pelvic soft tissue metastasis. The following months she received four cycles of carboplatin, paclitaxel, and temozolomide treatment. Three months following those treatments she developed headaches, nausea, vomiting, and confusion due to growth of the tumor and edema. Temodar was discontinued and she was given steroids. Subsequent scans revealed regressing disease until remission. As of 2017 she had perfect cognition and was running marathons, 11 years after diagnosis!!
"Notably, this patient never underwent craniotomy or whole brain radiation therapy and, consequently, avoided the related long-term neurocognitive toxicity of these interventions... We present a patient who is recurrence-free 11 years after the diagnosis of three brain metastases. Her treatment consisted of cytokine (interferon and interleukin-2) and chemotherapy nine months prior to developing brain and soft tissue metastases, which were treated with stereotactic radiosurgery and stereotactic ablative radiotherapy, respectively, followed by six months of chemotherapy. Notably, she has not received any treatment for over 10 years, never underwent craniotomy or whole brain radiation therapy, currently has a perfect score on the functional assessment of cancer therapy for brain (FACT-Br) quality of life (QoL) scale, and runs marathons. This treatment course is consistent with emerging literature on the abscopal effect (radiation-induced immune response). Clinical trials are needed to better understand and harness the abscopal effect in order to optimally integrate targeted drug and radiation therapies."
In this study they reference other long-term survivors who received:
a) Interferon, SRS, two craniotomies, chemotherapy
b) Craniotomy, vaccine, SRS
c) SRS, two craniotomies, chemotherapy
I haven't been able to check these case histories out yet but they are referenced for the above survivors:
- Somatic and germline analyses of a long term melanoma survivor with a recurrent brain metastasis. BMC Cancer. 2015, 23:926–931. 10.1186/s12885-015-1927-0
- Pulmonary sarcoid-like granulomatosis after multiple vaccinations of a long-term surviving patient with metastatic melanoma. Cancer Immunol Res. 2014, 2:1148–1153.
- Multiple brain metastases from malignant melanoma with long-term survival. Br J Neurosurg. 2004, 18:552–555. 10.1080/02688690400012616
Article - Preventing Drug Addiction in Cancer Patients
Including treatment and support resources... "Cancer doesn’t have to define you or steal your joy, and you don’t have to be a slave to addiction. If you’re seeking help for drug or alcohol addiction, or a co-occurring mental health disorder (depression, anxiety, eating disorder, etc.), you can find it at The Recovery Village®. Lines are open 24 hours a day, seven days a week, and there’s no obligation to enroll in treatment. So whether you’re ready to receive treatment or just need a listening ear, we’re here for you."
Study - The anti-cancer effect of amygdalin on human cancer cell lines.
"Our findings suggest that amygdalin might have an anticancer effect due to the various gene expressions in A549, MCF7, and AGS human cancer cells, showing it's potential as a natural therapeutic anticancer drug."
The Angiogenesis Foundation
Article - Tumor Angiogenesis as a Target for Dietary Cancer Prevention
Article - Antiangiogenesis in the Treatment of Skin Cancer (Vincent W. Li MD MBA, William W. Li MD)
(on the mechanism of cancer spreading in skin cancer and conventional methods used to treat it)
Study: 'Do the dietary supplements epigallocatechin gallate or vitamin e cause a radiomodifying response on tumors in vivo? A pilot study with murine breast carcinoma." (Is it safe to take antioxidants during radiation?)
EGCG slowed tumor growth rate by 10%. EGCG and VE slowed tumor regrowth by 24 to 25%... Normal tissues were protected from late radiation effects (autoamputations) in the VE group. VE and EGCG increased tumor cell apoptosis and decreased tumor cell proliferation but had no effect on microvessel density. In this pilot study, neither VE nor EGCG exerted a significant radiomodifying effect on the MCa-IV tumor. Nonetheless, the suggestion of a small degree of tumor radioprotection by these antioxidant compounds warrants further research.
Article: Should Patients Undergoing Chemotherapy and Radiotherapy Be Prescribed Antioxidants? (By Ralph Moss, PhD)
"In September 2005, CA: A Cancer Journal for Clinicians published a warning by Gabriella D’Andrea, MD, against the concurrent use of antioxidants with radiotherapy and chemotherapy. However, several deficiencies of the CA article soon became apparent, not least the selective omission of prominent studies that contradicted the author’s conclusions... A blanket rejection of the concurrent use of antioxidants with chemotherapy is not justified by the preponderance of evidence at this time and serves neither the scientific community nor cancer patients."
"The Danish Twin Study1 established that only about 20% of how long the average person lives is dictated by our genes, whereas the other 80% is dictated by our lifestyle. In 2004, Dan Buettner, CEO of Blue Zones LLC, was determined to uncover the specific aspects of lifestyle and environment that led to longevity.
By teaming up with National Geographic and the National Institute on Aging, Dan and his team, found the 5 demographically confirmed, geographically defined areas with the highest percentage of centenarians (Loma Linda, CA, USA; Nicoya, Costa Rica; Sardinia, Italy; Ikaria, Greece; Okinawa, Japan; seen in Figure 1). These 5 areas were located using epidemiological data, statistics, birth certificates, and other research. These areas were dubbed Blue Zones, where people reach age 100 at 10 times greater rates than in the United States. Once these areas were established, they sent in a team of anthropologists, demographers, epidemiologists, and researchers to identify the lifestyle characteristics that might explain longevity. They found that the lifestyles of all Blue Zones residents shared 9 specific characteristics. These are called the Power 9."
Article: The Budwig Diet and Cancer— Separating Flax from Fiction.
"Basic science suggests that flaxseed could have a very positive effect on cancer. Yet clinical research of flax in human cancer patients is almost entirely lacking... Long ago, as a member of the first advisory board of the Office of Alternative Medicine (OAM) of the National Institutes of Health (NIH), I fought to get the U.S. government to research the alternatives that were of interest to cancer patients. But, then and now, the NIH has not shown much interest in seriously examining popular alternatives.
As a result, they can truthfully say that such treatment has not been studied! They often state this as a criticism of proponents, rather than as a confession of their own failure to pursue promising leads."
My personal stance is that I recommend CBD products for nausea and pain relief without THC due to THC's psychotropic effects. There is also some question whether CBD can lead to liver toxicity when taken in conjunction with some pharmaceutical drugs. I am not sure of the frequency of this or if it can be alleviated with coffee enemas. If you have any questions or comments on this please email me! email@example.com. Thanks!
Review Article - A User’s Guide to Cannabinoid Therapies in Oncology
Study - Cannabidiol Enhances the Therapeutic Effects of TRAIL by Upregulating DR5 in Colorectal Cancer
"Cannabidiol, a major non-psychotomimetic compound derived from Cannabis sativa, is a potential therapeutic agent for a variety of diseases such as inflammatory diseases, chronic neurodegenerative diseases, and cancers. Here, we found that the combination of cannabidiol and TNF-related apoptosis-inducing ligand (TRAIL) produces synergistic antitumor effects in vitro. However, this synergistic effect was not observed in normal colonic cells. The levels of ER stress-related proteins, including C/EBP homologous protein (CHOP) and phosphorylated protein kinase RNA-like ER kinase (PERK) were increased in treatment of cannabidiol. Cannabidiol enhanced significantly DR5 expression by ER stress. Knockdown of DR5 decreased the combined effect of cannabidiol and TRAIL. Additionally, the combination of TRAIL and cannabidiol decreased tumor growth in xenograft models. Our studies demonstrate that cannabidiol enhances TRAIL-induced apoptosis by upregulating DR5 and suggests that cannabidiol is a novel agent for increasing sensitivity to TRAIL."
Article - Can THC and CBD Really Help with Nausea and Vomiting?
Study - Safety and Side Effects of Cannabidiol, a Cannabis sativa Constituent
Furthermore, CBD can inactivate human P450 3A4 , which is responsible for metabolizing more than 60% of clinically prescribed drugs "
Meta Analysis - Safety and Toxicology of Cannabinoids
Sources in California:
Here is a company that uses third party safety testing:
I checked out the lab that does the testing and as far as I can see they look legit: https://terpenesandtesting.com/cannabis-testing-lab-dvt/
It looks like this product from Green Spectrums might be the best one to start with since it contains a low dose:
I saw in this video that it would be best to start with 5-10mg of CBD, and one dropper full of the tincture above (the 250mg bottle) provides 8.33mg of CBD. However, the bottle only contains 30 servings so it might be better to get the 500mg bottle and you could do 1/3 the dropper to get 5mg of CBD and it would last you longer.
Article: CBD Lab Reports: Why They Are Important & How to Read Them
Article - Thymic hyperplasia following double immune checkpoint inhibitor therapy in two patients with stage IV melanoma.
"These are the first described cases of true thymic hyperplasia following combination immune checkpoint inhibitor therapy for metastatic melanoma. We hypothesize that the true thymic hyperplasia in these cases results from initial lymphocyte depletion caused by intense corticosteroid therapy followed by rebound thymic hyperplasia during the period of relative hypocortisolism, which may have been aggravated by the onset of secondary hypoadrenalism."
My personal stance is that there are times when chemotherapy may be appropriate, such as if alternatives were tried and the cancer growth did not slow down and if it used via IPT (insulin potentiation therapy) in which the chemo is given in lower doses, and in combination with other complementary therapies such as major diet and lifestyle modifications, IV therapies and/or fasting. With that said, cancer researcher Ralph Moss discusses the downfalls of chemotherapy used in conventional settings in the following article:
When Chemo Kills: The Inside Story
I don't often hear of any negative side effects from coffee enemas but this article (in Korean language) provides some information on its potential negative effects. References are in English, and some are not related to coffee enemas themselves but barium, saline and hydrogen peroxide enemas.
Results and insights on 896 of Dr. William Coley's patients by his daughter, Helen Coley Nauts, including the importance of fever on survival.
Article - Beyond Magic Bullets: Helen Coley Nauts and the Battle for Immunotherapy (Cancer Research Institute)
Review - Dr William Coley and tumour regression: a place in history or in the future (Hoption Cann, van Netten, van Netten)
Article - Fever and Cancer in Perspective (by Uwe Hobohm)
(Full-text requested and will be added here if approved)
Article - Helen C. Nauts, 93, Champion Of Her Father's Cancer Work (New York Times)
Article - The Treatment of Malignant Tumors by Repeated Inoculations of Erysipelas: with a Report of Ten Original Cases. (William Coley)
Review by the American Cancer Society calling Coley's Toxins quackery - Unproven Methods of Cancer Treatment Coley's Mixed Toxins (found on the US National Library of Medicine website,
Blog post - What Is Coley Fluid
Article - Metabolic Endotoxemia: The Link Between the Chronic Diseases and the Saturated Fats You Want to Avoid
Study - Oxygen-ozone therapy as support and palliative therapy in 50 cancer patients with fatigue – A short report
"Patients were treated with Auto Hemotransfusion (GAE) according to the SIOOT (Scientific Society of Oxygen Ozone Therapy) protocols, two times a week for one month and then twice monthly as maintenance therapy... No side effects were found, and 35 patients (70%) achieved a significant improvement (> 50%) of the symptoms. Our preliminary data demonstrate that ozone therapy is a valid supportive therapy for fatigue in cancer patients, both during cancer therapy and in a palliative setting with no significant side effects."
Study - Fat, fibre and cancer risk in African Americans and rural Africans
Article - Frankincense Oil Kills Chemo-Resistant Cancer Cells Without Damaging Healthy Cells, Studies Show
"Unequivocal data regarding the effects of multiple GBCA exposure are limited. However, the information regarding the thermodynamic stability constants for GBCAs, in vitro, animal, and human data, and the emerging data regarding gadolinium tissue accumulation in those with normal kidney function indicate that the potential toxicity associated with GBCA must be seriously and urgently considered. This concept must be addressed with retrospective and prospective cohort studies. Research providing additional mechanistic data is also paramount and will provide valuable information regarding how to prevent GBCA-related toxicity, treat existing GBCA-related health issues, guide the use of existing GBCAs, and direct the design of safer MRI contrast agents."
Study - The Influence of Heating on the Anticancer Properties of Garlic
"Allyl sulfur compounds are the major active constituents found in crushed garlic. Research has revealed that garlic and its lipid- or water-soluble components have many pharmacologic properties; however, studies also demonstrate that heating has a negative influence on these beneficial effects... These studies suggest that heating destroyed garlic's active allyl sulfur compound formation, which may relate to its anticancer properties."
Gerson Matzinger - Practice of Gerson’s diet therapy in neoplastic diseases: A tissue-centric nutritional immunotherapy that anticipated Matzinger’s Danger Model with its tissue-based effector class control
Article - Temperature Matters! And Why it Should Matter to Tumor Immunologists
"These discoveries suggest that mild hyperthermia may be an effective noninvasive strategy for manipulating the tumor microenvironment in specific ways that could enhance immunotherapy... A major concept being explored by researchers in Thermal Medicine is that application of heat to a specific region of the body (in the absence of fever) may result in a significant counter reaction aimed at restoring the normal temperature of the affected region. These counter reactions might alter the physiology of the tumor microenvironment, altering the immune response. Importantly, fever and hyperthermia share a dependence upon activation of heat shock factor 1, (HSF-1) (14) suggesting a common stress induced pathway could account for some of the similar effects of each process on the immune response.
Study - Hyperthermia enhances photodynamic therapy by regulation of HCP1 and ABCG2 expressions via high level ROS generation.
Hyperthermia increases the cytotoxic effects of photodynamic therapy.
Article - Where to get photodynamic therapy:
Study - Biofunctionalization of magnetite nanoparticles with stevioside: effect on the size and thermal behaviour for use in hyperthermia applications
Stevia compound-coated nanomagnets help increase efficacy of hyperthermia in killing rat glioma cells.
"Our finding suggests superior properties of stevioside-coated magnetite nanoparticles in comparison to polysorbate-80 and oleic acid coated nanomagnets as far as particle size reduction, biocompatibility, hyperthermic effect, and cellular uptake by the glioblastoma cancer cells are concerned. The stevioside-coated nanomagnets exhibiting the maximum temperature rise were further investigated as heating agents in in vitro magnetic hyperthermia experiments (405 kHz, 168 Oe), showing their efficacy to induce cell death of rat C6 glioma cells after 30 min at a target temperature T = 43 °C."
Study - Adjuvant Effect of Molecular Iodine in Conventional Chemotherapy for Breast Cancer. Randomized Pilot Study
"Our data indicate that supplementation with I2 improves the effectiveness of the treatment, decreasing side effects and increasing disease-free survival specially in advanced conditions (stage III). We also show that iodine supplementation induces tumor re-differentiation and the reactivation of antitumor immune responses. This study establishes a framework for the proposal of a phase III study for the analysis of iodine supplementation in the treatment of advanced breast cancer."
Study - Active Chinese mistletoe lectin-55 enhances colon cancer surveillance through regulating innate and adaptive immune responses.
https://www.ncbi.nlm.nih.gov/pubmed/18785279 (Full text available at https://www.wjgnet.com/1007-9327/full/v14/i34/5274.htm)
Modified Citrus Pectin
Studies on Modified Citrus Pectin and melanoma reveal that MCP may reduce the risk of metastasis.
Study - Galectin-3 expressed on different lung compartments promotes organ specific metastasis by facilitating arrest, extravasation and organ colonization via high affinity ligands on melanoma cells.
"Metastasis could also be inhibited by blocking surface polyLacNAc by pre-incubating cells with truncated galectin-3 (which lacked oligomerization domain) or by feeding mice with modified citrus pectin in drinking water. Overall, these results unequivocally show that polyLacNAc on melanoma cells and galectin-3 on the lungs play a critical role in arrest and extravasation of cells in the lungs and strategies that target these interactions inhibit lung metastasis."
Study - Effects of natural complex carbohydrate (citrus pectin) on murine melanoma cell properties related to galectin-3 functions.
"We reported previously that intravenous injection of B16-F1 murine melanoma cells with CP or MCP into syngeneic mice resulted in a significant increase or decrease of lung colonization, respectively (Platt D, Raz A (1992) J Natl Cancer Inst 84:438-42). Here we studied the effects of these polysaccharides on cell-cell and cell-matrix interactions mediated by carbohydrate-recognition. MCP, but not CP, inhibited B16-F1 melanoma cells adhesion to laminin and asialofetuin-induced homotypic aggregation. Both polysaccharides inhibited anchorage-independent growth of B16-F1 cells in semisolid medium, i.e. agarose. These results indicate that carbohydrate-recognition by cell surface galectin-3 may be involved in cell-extracellular matrix interaction and play a role in anchorage-independent growth as well as the in vivo embolization of tumour cells."
Study - Modulation of the lung colonization of B16-F1 melanoma cells by citrus pectin.
"Successful interference with such a process with MCP may lead to a reduced ability to form tumor cell emboli and metastasis."
Study - The antiproliferative effects of cold atmospheric plasma-activated media on different cancer cell lines, the implication of ozone as a possible underlying mechanism.
[Appears to act as an antiviral and antibiotic agent. Was recommended to me by Dr. Anna Pavlick, MD from NYU Langone Cancer Center when she discovered it killed melanoma cells in her lab.]
Study - Modulation of chemotherapy with para-amino benzoic acid (PABA): Translation from preclinical models to a completed phase I trial
"We observed inflammatory responses in responding cutaneous lesions." (which could be a good thing! This often happens during Coley's toxins injections
Study - Production of Antifungal p-Aminobenzoic Acid in Lysobacter antibioticus OH13.
Study - The folate precursor para-aminobenzoic acid elicits induced resistance against Cucumber mosaic virus and Xanthomonas axonopodis.
"Unexpectedly, fruit yield was increased in PABA-treated plants, indicating that PABA-mediated SAR successfully protected pepper plants from infection by bacterial and viral pathogens without significant fitness allocation costs."
Study - Antihyperalgesic effects of ashwagandha (Withania somnifera root extract) in rat models of postoperative and neuropathic pain.
Study - The ability of positron emission tomography/computed tomography to detect synchronous colonic cancers in patients with obstructive colorectal cancer.
Study - The value of using fludeoxyglucose positron-emission tomography scan with respect to colorectal abnormalities-a cross-sectional study.
Article - Where to get photodynamic therapy:
Study - Hyperthermia enhances photodynamic therapy by regulation of HCP1 and ABCG2 expressions via high level ROS generation.
Hyperthermia increases the cytotoxic effects of photodynamic therapy.
Article - Potential Synergy of Phytochemicals in Cancer Prevention: Mechanism of Action (Rui Hai Liu)
Study - Selenium does not affect radiosensitivity of breast cancer cell lines.
"The data suggest that physiological relevant selenium concentrations administered in combination with radiation therapy do not deteriorate the efficacy of radiotherapy in breast cancer patients."
Article - Tumor Microenvironment as A “Game Changer” in Cancer Radiotherapy
"Low doses [of radiation therapy, RT] slightly activate the antitumor response, without significant impact on the cancer blood vessels, which does not damage the entire tumor. High doses activate the antitumor immune response but also cause destruction, with huge regions of hypoxia that trigger renewal processes that lead to a regrowth of the tumor. In both cases, cancer may recur. Therefore, further studies investigating the effect of dose and RT schema on the TME [tumor microenvironment] are necessary. The acquired knowledge should be used to develop a treatment regimen that will destroy cancer cells and use the surrounding environment to effectively fight cancer. The key is to understand that TME is a “game changer” in the RT fight against cancer. Ignoring this information leads to therapy failure. Following these may lead to designing an effective combination therapy—radiotherapy with drugs that will prevent the unwanted, negative changes occurring in the tumor microenvironment. https://www.mdpi.com/1422-0067/20/13/3212/htm
Pooling all comparisons, soy food intake after diagnosis was associated with reduced mortality and recurrence. Pooling the comparisons of highest vs. lowest dose, soy food intake after diagnosis was again associated with reduced mortality and recurrence. Subgroup analysis of ER status showed that soy food intake was associated with reduced mortality in both ER negative and ER positive patients, and both premenopausal and postmenopausal patients. In addition, soy food intake was associated with reduced recurrence in ER negative and ER+/PR+, and postmenopausal patients. Conclusion: Our meta-analysis showed that soy food intake might be associated with better survival, especially for ER negative, ER+/ PR+, and postmenopausal patients.
Study - Influence of soy isoflavones in breast cancer angiogenesis: a multiplex glass ELISA approach